| Game | Time (ET) | Winning Team | Losing Team | Arena | City | State |
|---|---|---|---|---|---|---|
| NBA 2021-05-16: PHX 123 at SAS 121 | May 16, 2021, 7 a.m. | PHX | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-05-15: PHX 140 at SAS 103 | May 15, 2021, 7 a.m. | PHX | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-05-13: SAS 98 at NYK 102 | May 13, 2021, 12:30 p.m. | NYK | SAS | Madison Square Garden | New York | NY |
| NBA 2021-05-12: SAS 116 at BKN 128 | May 12, 2021, 1 p.m. | BKN | SAS | Barclays Center | Brooklyn | NY |
| NBA 2021-05-10: MIL 125 at SAS 146 | May 10, 2021, 1:30 p.m. | SAS | MIL | AT&T Center | San Antonio | TX |
| NBA 2021-05-08: SAS 102 at POR 124 | May 8, 2021, 3 p.m. | POR | SAS | Moda Center | Portland | OR |
| NBA 2021-05-07: SAS 113 at SAC 104 | May 7, 2021, 3 p.m. | SAS | SAC | Golden 1 Center | Sacramento | CA |
| NBA 2021-05-05: SAS 94 at UTA 126 | May 5, 2021, 2 p.m. | UTA | SAS | Vivint Arena | Salt Lake City | UT |
| NBA 2021-05-03: SAS 99 at UTA 110 | May 3, 2021, 3 p.m. | UTA | SAS | Vivint Arena | Salt Lake City | UT |
| NBA 2021-05-02: PHI 113 at SAS 111 (OT) | May 2, 2021, 1 p.m. | PHI | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-04-30: SAS 140 at BOS 143 (OT) | April 30, 2021, 12:30 p.m. | BOS | SAS | TD Garden | Boston | MA |
| NBA 2021-04-28: SAS 111 at MIA 116 | April 28, 2021, 1 p.m. | MIA | SAS | AmericanAirlines Arena | Miami | FL |
| NBA 2021-04-26: SAS 146 at WAS 143 (OT) | April 26, 2021, noon | SAS | WAS | Capital One Arena | Washington | DC |
| NBA 2021-04-24: SAS 110 at NOP 108 | April 24, 2021, 1 p.m. | SAS | NOP | Smoothie King Center | New Orleans | LA |
| NBA 2021-04-22: DET 91 at SAS 106 | April 22, 2021, 1:30 p.m. | SAS | DET | AT&T Center | San Antonio | TX |
| NBA 2021-04-21: MIA 107 at SAS 87 | April 21, 2021, 1:30 p.m. | MIA | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-04-19: SAS 109 at IND 94 | April 19, 2021, 1 p.m. | SAS | IND | Bankers Life Fieldhouse | Indianapolis | IN |
| NBA 2021-04-17: SAS 111 at PHX 85 | April 17, 2021, 3 p.m. | SAS | PHX | Phoenix Suns Arena | Phoenix | AZ |
| NBA 2021-04-16: POR 107 at SAS 106 | April 16, 2021, 1:30 p.m. | POR | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-04-14: SAS 112 at TOR 117 | April 14, 2021, 12:30 p.m. | TOR | SAS | Amalie Arena | Tampa | FL |
| NBA 2021-04-12: SAS 120 at ORL 97 | April 12, 2021, 1 p.m. | SAS | ORL | Amway Center | Orlando | FL |
| NBA 2021-04-11: SAS 119 at DAL 117 | April 11, 2021, 1 p.m. | SAS | DAL | American Airlines Center | Dallas | TX |
| NBA 2021-04-09: SAS 119 at DEN 121 | April 9, 2021, 2 p.m. | DEN | SAS | Ball Arena | Denver | CO |
| NBA 2021-04-07: SAS 96 at DEN 106 | April 7, 2021, 2 p.m. | DEN | SAS | Ball Arena | Denver | CO |
| NBA 2021-04-05: CLE 125 at SAS 101 | April 5, 2021, noon | CLE | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-04-03: IND 139 at SAS 133 (OT) | April 3, 2021, 2 p.m. | IND | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-04-01: ATL 134 at SAS 129 (OT) | April 1, 2021, 1:30 p.m. | ATL | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-03-31: SAC 106 at SAS 120 | March 31, 2021, 1:30 p.m. | SAS | SAC | AT&T Center | San Antonio | TX |
| NBA 2021-03-29: SAC 132 at SAS 115 | March 29, 2021, 1:30 p.m. | SAC | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-03-27: CHI 104 at SAS 120 | March 27, 2021, 1:30 p.m. | SAS | CHI | AT&T Center | San Antonio | TX |
| NBA 2021-03-25: LAC 98 at SAS 85 | March 25, 2021, 1:30 p.m. | LAC | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-03-24: LAC 134 at SAS 101 | March 24, 2021, 1:30 p.m. | LAC | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-03-22: CHA 100 at SAS 97 | March 22, 2021, 1:30 p.m. | CHA | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-03-20: SAS 113 at MIL 120 | March 20, 2021, 2 p.m. | MIL | SAS | Fiserv Forum | Milwaukee | WI |
| NBA 2021-03-19: SAS 116 at CLE 110 | March 19, 2021, 12:30 p.m. | SAS | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |