| Game | Q1 | Q2 | Q3 | Q4 | OT | +/- Q1 | +/- Q2 | +/- Q3 | +/- Q4 | +/- OT | LL | PP | 2CP | FBP | OTP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NBA 2021-05-16: CLE 109 at BKN 123 | 24 | 32 | 20 | 33 | 0 | -10 | -1 | -12 | 9 | 0 | 0 | 48 | 19 | 8 | 28 |
| NBA 2021-05-14: CLE 105 at WAS 120 | 33 | 23 | 20 | 29 | 0 | 2 | -4 | -13 | 0 | 0 | 7 | 50 | 10 | 6 | 21 |
| NBA 2021-05-12: BOS 94 at CLE 102 | 22 | 20 | 25 | 35 | 0 | 5 | -2 | -5 | 10 | 0 | 13 | 44 | 9 | 4 | 12 |
| NBA 2021-05-10: IND 111 at CLE 102 | 28 | 32 | 17 | 25 | 0 | 1 | 6 | -9 | -7 | 0 | 10 | 40 | 17 | 13 | 15 |
| NBA 2021-05-09: DAL 124 at CLE 97 | 30 | 23 | 19 | 25 | 0 | -9 | -2 | -15 | -1 | 0 | 0 | 32 | 19 | 5 | 16 |
| NBA 2021-05-07: CLE 90 at DAL 110 | 19 | 18 | 28 | 25 | 0 | -14 | -11 | 4 | 1 | 0 | 2 | 48 | 15 | 9 | 22 |
| NBA 2021-05-05: POR 141 at CLE 105 | 28 | 29 | 23 | 25 | 0 | -1 | -9 | -12 | -14 | 0 | 5 | 34 | 25 | 9 | 8 |
| NBA 2021-05-04: PHX 134 at CLE 118 (OT) | 24 | 29 | 35 | 26 | 4 | -6 | 0 | 4 | 2 | -16 | 4 | 54 | 15 | 12 | 23 |
| NBA 2021-05-01: MIA 124 at CLE 107 | 36 | 24 | 26 | 21 | 0 | 7 | -14 | -6 | -4 | 0 | 11 | 30 | 11 | 5 | 24 |
| NBA 2021-04-30: WAS 122 at CLE 93 | 30 | 22 | 16 | 25 | 0 | -5 | -1 | -17 | -6 | 0 | 4 | 46 | 11 | 10 | 30 |
| NBA 2021-04-28: ORL 109 at CLE 104 | 16 | 28 | 17 | 43 | 0 | -10 | 4 | -15 | 16 | 0 | 2 | 46 | 6 | 12 | 10 |
| NBA 2021-04-26: CLE 96 at TOR 112 | 23 | 25 | 22 | 26 | 0 | -10 | 9 | -10 | -5 | 0 | 8 | 48 | 19 | 7 | 18 |
| NBA 2021-04-25: CLE 110 at WAS 119 | 32 | 28 | 33 | 17 | 0 | 5 | -8 | 9 | -15 | 0 | 8 | 54 | 14 | 8 | 21 |
| NBA 2021-04-23: CLE 102 at CHA 108 | 20 | 35 | 23 | 24 | 0 | -2 | 9 | -7 | -6 | 0 | 10 | 56 | 9 | 11 | 18 |
| NBA 2021-04-21: CHI 105 at CLE 121 | 34 | 27 | 38 | 22 | 0 | 22 | -5 | 10 | -11 | 0 | 33 | 56 | 12 | 8 | 15 |
| NBA 2021-04-19: CLE 105 at DET 109 | 22 | 31 | 23 | 29 | 0 | -15 | 6 | 1 | 4 | 0 | 3 | 68 | 9 | 6 | 17 |
| NBA 2021-04-17: CLE 96 at CHI 106 | 24 | 25 | 21 | 26 | 0 | -5 | 7 | -12 | 0 | 0 | 6 | 42 | 13 | 6 | 14 |
| NBA 2021-04-15: GSW 119 at CLE 101 | 31 | 21 | 27 | 22 | 0 | 3 | -14 | 1 | -8 | 0 | 11 | 44 | 4 | 13 | 22 |
| NBA 2021-04-14: CLE 103 at CHA 90 | 27 | 22 | 26 | 28 | 0 | 4 | 4 | 1 | 4 | 0 | 13 | 42 | 10 | 13 | 13 |
| NBA 2021-04-11: NOP 116 at CLE 109 | 39 | 29 | 26 | 15 | 0 | 10 | -4 | -2 | -11 | 0 | 13 | 48 | 16 | 15 | 12 |
| NBA 2021-04-10: TOR 135 at CLE 115 | 26 | 28 | 29 | 32 | 0 | -21 | -12 | 16 | -3 | 0 | 2 | 46 | 10 | 12 | 19 |
| NBA 2021-04-08: CLE 129 at OKC 102 | 38 | 27 | 28 | 36 | 0 | 0 | 4 | 14 | 9 | 0 | 29 | 58 | 15 | 13 | 8 |
| NBA 2021-04-05: CLE 125 at SAS 101 | 28 | 29 | 43 | 25 | 0 | 2 | 8 | 10 | 4 | 0 | 32 | 60 | 8 | 21 | 14 |
| NBA 2021-04-03: CLE 101 at MIA 115 | 27 | 27 | 19 | 28 | 0 | -9 | -4 | 2 | -3 | 0 | 5 | 42 | 9 | 7 | 16 |
| NBA 2021-04-01: PHI 114 at CLE 94 | 31 | 25 | 17 | 21 | 0 | 0 | -2 | -10 | -8 | 0 | 8 | 40 | 6 | 15 | 20 |
| NBA 2021-03-29: CLE 75 at UTA 114 | 18 | 16 | 18 | 23 | 0 | -9 | -10 | -19 | -1 | 0 | 0 | 34 | 10 | 5 | 12 |
| NBA 2021-03-27: CLE 98 at SAC 100 | 29 | 19 | 26 | 24 | 0 | -2 | 1 | 4 | -5 | 0 | 8 | 56 | 8 | 4 | 9 |
| NBA 2021-03-26: CLE 86 at LAL 100 | 24 | 27 | 10 | 25 | 0 | 2 | 5 | -18 | -3 | 0 | 10 | 42 | 9 | 7 | 21 |
| NBA 2021-03-24: CLE 103 at CHI 94 | 25 | 28 | 25 | 25 | 0 | 0 | -2 | 8 | 3 | 0 | 13 | 56 | 19 | 4 | 14 |
| NBA 2021-03-22: SAC 119 at CLE 105 | 35 | 24 | 17 | 29 | 0 | -1 | -3 | -10 | 0 | 0 | 3 | 68 | 16 | 20 | 5 |
| NBA 2021-03-21: TOR 105 at CLE 116 | 23 | 36 | 32 | 25 | 0 | -5 | 7 | 14 | -5 | 0 | 22 | 40 | 9 | 9 | 26 |
| NBA 2021-03-19: SAS 116 at CLE 110 | 22 | 20 | 24 | 44 | 0 | -3 | -9 | -3 | 9 | 0 | 0 | 52 | 18 | 9 | 11 |
| NBA 2021-03-17: BOS 110 at CLE 117 | 26 | 29 | 27 | 35 | 0 | 8 | 9 | -9 | -1 | 0 | 21 | 56 | 12 | 11 | 25 |
| NBA 2021-03-16: CLE 98 at MIA 113 | 26 | 22 | 28 | 22 | 0 | -11 | -3 | -5 | 4 | 0 | 4 | 58 | 24 | 4 | 17 |
| NBA 2021-03-14: CLE 82 at ATL 100 | 22 | 24 | 20 | 16 | 0 | -4 | 1 | 0 | -15 | 0 | 5 | 42 | 19 | 3 | 14 |