| Game | Time (ET) | Winning Team | Losing Team | Arena | City | State |
|---|---|---|---|---|---|---|
| NBA 2022-04-10: SAS 120 at DAL 130 | April 10, 2022, 9:30 p.m. | DAL | SAS | American Airlines Center | Dallas | TX |
| NBA 2022-04-09: GSW 100 at SAS 94 | April 9, 2022, 8:30 p.m. | GSW | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-04-07: SAS 121 at MIN 127 | April 7, 2022, 8 p.m. | MIN | SAS | Target Center | Minneapolis | MN |
| NBA 2022-04-05: SAS 116 at DEN 97 | April 5, 2022, 9 p.m. | SAS | DEN | Ball Arena | Denver | CO |
| NBA 2022-04-03: POR 92 at SAS 113 | April 3, 2022, 7 p.m. | SAS | POR | AT&T Center | San Antonio | TX |
| NBA 2022-04-01: POR 111 at SAS 130 | April 1, 2022, 8:30 p.m. | SAS | POR | AT&T Center | San Antonio | TX |
| NBA 2022-03-30: MEM 112 at SAS 111 | March 30, 2022, 8:30 p.m. | MEM | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-03-28: SAS 123 at HOU 120 | March 28, 2022, 8 p.m. | SAS | HOU | Toyota Center | Houston | TX |
| NBA 2022-03-26: SAS 107 at NOP 103 | March 26, 2022, 5 p.m. | SAS | NOP | Smoothie King Center | New Orleans | LA |
| NBA 2022-03-23: SAS 133 at POR 96 | March 23, 2022, 10 p.m. | SAS | POR | Moda Center | Portland | OR |
| NBA 2022-03-20: SAS 110 at GSW 108 | March 20, 2022, 8:30 p.m. | SAS | GSW | Chase Center | San Francisco | CA |
| NBA 2022-03-18: NOP 124 at SAS 91 | March 18, 2022, 8:30 p.m. | NOP | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-03-16: OKC 120 at SAS 122 | March 16, 2022, 8:30 p.m. | SAS | OKC | AT&T Center | San Antonio | TX |
| NBA 2022-03-14: MIN 149 at SAS 139 | March 14, 2022, 8:30 p.m. | MIN | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-03-12: IND 119 at SAS 108 | March 12, 2022, 8 p.m. | IND | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-03-11: UTA 102 at SAS 104 | March 11, 2022, 8:30 p.m. | SAS | UTA | AT&T Center | San Antonio | TX |
| NBA 2022-03-09: TOR 119 at SAS 104 | March 9, 2022, 8:30 p.m. | TOR | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-03-07: LAL 110 at SAS 117 | March 7, 2022, 8:30 p.m. | SAS | LAL | AT&T Center | San Antonio | TX |
| NBA 2022-03-05: SAS 117 at CHA 123 | March 5, 2022, 7 p.m. | CHA | SAS | Spectrum Center | Charlotte | NC |
| NBA 2022-03-03: SAC 115 at SAS 112 | March 3, 2022, 8:30 p.m. | SAC | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-02-28: SAS 105 at MEM 118 | Feb. 28, 2022, 8 p.m. | MEM | SAS | FedExForum | Memphis | TN |
| NBA 2022-02-26: SAS 129 at MIA 133 | Feb. 26, 2022, 8 p.m. | MIA | SAS | FTX Arena | Miami | FL |
| NBA 2022-02-25: SAS 157 at WAS 153 (OT) | Feb. 25, 2022, 7 p.m. | SAS | WAS | Capital One Arena | Washington | DC |
| NBA 2022-02-16: SAS 114 at OKC 106 | Feb. 16, 2022, 8 p.m. | SAS | OKC | Paycom Center | Oklahoma City | OK |
| NBA 2022-02-14: SAS 109 at CHI 120 | Feb. 14, 2022, 8 p.m. | CHI | SAS | United Center | Chicago | IL |
| NBA 2022-02-12: SAS 124 at NOP 114 | Feb. 12, 2022, 7 p.m. | SAS | NOP | Smoothie King Center | New Orleans | LA |
| NBA 2022-02-11: SAS 136 at ATL 121 | Feb. 11, 2022, 7:30 p.m. | SAS | ATL | State Farm Arena | Atlanta | GA |
| NBA 2022-02-09: SAS 92 at CLE 105 | Feb. 9, 2022, 7 p.m. | CLE | SAS | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-02-04: HOU 106 at SAS 131 | Feb. 4, 2022, 8:30 p.m. | SAS | HOU | AT&T Center | San Antonio | TX |
| NBA 2022-02-03: MIA 112 at SAS 95 | Feb. 3, 2022, 7 p.m. | MIA | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-02-01: GSW 124 at SAS 120 | Feb. 1, 2022, 8:30 p.m. | GSW | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-01-30: SAS 110 at PHX 115 | Jan. 30, 2022, 8 p.m. | PHX | SAS | Footprint Center | Phoenix | AZ |
| NBA 2022-01-28: CHI 122 at SAS 131 | Jan. 28, 2022, 8:30 p.m. | SAS | CHI | AT&T Center | San Antonio | TX |
| NBA 2022-01-26: MEM 118 at SAS 110 | Jan. 26, 2022, 8:30 p.m. | MEM | SAS | AT&T Center | San Antonio | TX |
| NBA 2022-01-25: SAS 134 at HOU 104 | Jan. 25, 2022, 8 p.m. | SAS | HOU | Toyota Center | Houston | TX |