| Game | Time (ET) | Winning Team | Losing Team | Arena | City | State |
|---|---|---|---|---|---|---|
| NBA 2022-04-10: DET 106 at PHI 118 | April 10, 2022, 7 p.m. | PHI | DET | Wells Fargo Center | Philadelphia | PA |
| NBA 2022-04-08: MIL 131 at DET 101 | April 8, 2022, 7 p.m. | MIL | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-04-06: DAL 131 at DET 113 | April 6, 2022, 7 p.m. | DAL | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-04-03: DET 121 at IND 117 | April 3, 2022, 5 p.m. | DET | IND | Gainbridge Fieldhouse | Indianapolis | IN |
| NBA 2022-04-01: DET 110 at OKC 101 | April 1, 2022, 8 p.m. | DET | OKC | Paycom Center | Oklahoma City | OK |
| NBA 2022-03-31: PHI 94 at DET 102 | March 31, 2022, 7 p.m. | DET | PHI | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-29: DET 123 at BKN 130 | March 29, 2022, 7:30 p.m. | BKN | DET | Barclays Center | Brooklyn | NY |
| NBA 2022-03-27: NYK 104 at DET 102 | March 27, 2022, 3:30 p.m. | NYK | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-25: WAS 100 at DET 97 | March 25, 2022, 7 p.m. | WAS | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-23: ATL 101 at DET 122 | March 23, 2022, 7 p.m. | DET | ATL | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-21: POR 119 at DET 115 | March 21, 2022, 7 p.m. | POR | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-19: DET 109 at CLE 113 | March 19, 2022, 8 p.m. | CLE | DET | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-17: DET 134 at ORL 120 | March 17, 2022, 7 p.m. | DET | ORL | Amway Center | Orlando | FL |
| NBA 2022-03-15: DET 98 at MIA 105 | March 15, 2022, 7:30 p.m. | MIA | DET | FTX Arena | Miami | FL |
| NBA 2022-03-13: LAC 106 at DET 102 | March 13, 2022, 3 p.m. | LAC | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-11: DET 103 at BOS 114 | March 11, 2022, 7:30 p.m. | BOS | DET | TD Garden | Boston | MA |
| NBA 2022-03-09: CHI 114 at DET 108 | March 9, 2022, 7 p.m. | CHI | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-07: ATL 110 at DET 113 (OT) | March 7, 2022, 7 p.m. | DET | ATL | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-04: IND 106 at DET 111 | March 4, 2022, 7 p.m. | DET | IND | Little Caesars Arena | Detroit | MI |
| NBA 2022-03-03: DET 108 at TOR 106 | March 3, 2022, 7:30 p.m. | DET | TOR | Scotiabank Arena | Toronto | ON |
| NBA 2022-03-01: DET 113 at WAS 116 | March 1, 2022, 7 p.m. | WAS | DET | Capital One Arena | Washington | DC |
| NBA 2022-02-27: DET 127 at CHA 126 (OT) | Feb. 27, 2022, 7 p.m. | DET | CHA | Spectrum Center | Charlotte | NC |
| NBA 2022-02-26: BOS 113 at DET 104 | Feb. 26, 2022, noon | BOS | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-02-24: CLE 103 at DET 106 | Feb. 24, 2022, 7 p.m. | DET | CLE | Little Caesars Arena | Detroit | MI |
| NBA 2022-02-16: DET 112 at BOS 111 | Feb. 16, 2022, 7:30 p.m. | DET | BOS | TD Garden | Boston | MA |
| NBA 2022-02-14: DET 94 at WAS 103 | Feb. 14, 2022, 7 p.m. | WAS | DET | Capital One Arena | Washington | DC |
| NBA 2022-02-11: CHA 141 at DET 119 | Feb. 11, 2022, 7 p.m. | CHA | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-02-10: MEM 132 at DET 107 | Feb. 10, 2022, 7 p.m. | MEM | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-02-08: DET 86 at DAL 116 | Feb. 8, 2022, 8:30 p.m. | DAL | DET | American Airlines Center | Dallas | TX |
| NBA 2022-02-06: DET 105 at MIN 118 | Feb. 6, 2022, 3:30 p.m. | MIN | DET | Target Center | Minneapolis | MN |
| NBA 2022-02-04: BOS 102 at DET 93 | Feb. 4, 2022, 7 p.m. | BOS | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-02-03: MIN 128 at DET 117 | Feb. 3, 2022, 7 p.m. | MIN | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-02-01: NOP 111 at DET 101 | Feb. 1, 2022, 7 p.m. | NOP | DET | Little Caesars Arena | Detroit | MI |
| NBA 2022-01-30: CLE 105 at DET 115 | Jan. 30, 2022, 6 p.m. | DET | CLE | Little Caesars Arena | Detroit | MI |
| NBA 2022-01-28: DET 103 at ORL 119 | Jan. 28, 2022, 7 p.m. | ORL | DET | Amway Center | Orlando | FL |