| Game | Time (ET) | Winning Team | Losing Team | Arena | City | State |
|---|---|---|---|---|---|---|
| NBA 2021-10-15: HOU 98 at SAS 126 | Oct. 15, 2021, 1:30 p.m. | SAS | HOU | AT&T Center | San Antonio | TX |
| NBA 2021-10-10: SAS 101 at ORL 100 | Oct. 10, 2021, 11 a.m. | SAS | ORL | Amway Center | Orlando | FL |
| NBA 2021-10-08: MIA 109 at SAS 105 | Oct. 8, 2021, 1:30 p.m. | MIA | SAS | AT&T Center | San Antonio | TX |
| NBA 2021-10-06: SAS 105 at DET 115 | Oct. 6, 2021, noon | DET | SAS | Little Caesars Arena | Detroit | MI |
| NBA 2021-10-04: UTA 85 at SAS 111 | Oct. 4, 2021, 1:30 p.m. | SAS | UTA | AT&T Center | San Antonio | TX |