| Game | Date | Winning Team | Losing Team | Arena | City | State |
|---|---|---|---|---|---|---|
| NBA 2022-04-10: MIL 115 at CLE 133 | Apr 10, 2022 | CLE | MIL | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-04-08: CLE 107 at BKN 118 | Apr 08, 2022 | BKN | CLE | Barclays Center | Brooklyn | NY |
| NBA 2022-04-05: CLE 115 at ORL 120 | Apr 05, 2022 | ORL | CLE | Amway Center | Orlando | FL |
| NBA 2022-04-03: PHI 112 at CLE 108 | Apr 03, 2022 | PHI | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-04-02: CLE 119 at NYK 101 | Apr 02, 2022 | CLE | NYK | Madison Square Garden | New York | NY |
| NBA 2022-03-31: CLE 107 at ATL 131 | Mar 31, 2022 | ATL | CLE | State Farm Arena | Atlanta | GA |
| NBA 2022-03-30: DAL 120 at CLE 112 | Mar 30, 2022 | DAL | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-28: ORL 101 at CLE 107 | Mar 28, 2022 | CLE | ORL | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-26: CHI 98 at CLE 94 | Mar 26, 2022 | CHI | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-24: CLE 104 at TOR 117 | Mar 24, 2022 | TOR | CLE | Scotiabank Arena | Toronto | ON |
| NBA 2022-03-21: LAL 131 at CLE 120 | Mar 21, 2022 | LAL | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-19: DET 109 at CLE 113 | Mar 19, 2022 | CLE | DET | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-18: DEN 116 at CLE 119 (OT) | Mar 18, 2022 | CLE | DEN | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-16: PHI 118 at CLE 114 | Mar 16, 2022 | PHI | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-14: LAC 111 at CLE 120 (OT) | Mar 14, 2022 | CLE | LAC | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-12: CLE 91 at CHI 101 | Mar 12, 2022 | CHI | CLE | United Center | Chicago | IL |
| NBA 2022-03-11: CLE 105 at MIA 117 | Mar 11, 2022 | MIA | CLE | FTX Arena | Miami | FL |
| NBA 2022-03-08: CLE 127 at IND 124 | Mar 08, 2022 | CLE | IND | Gainbridge Fieldhouse | Indianapolis | IN |
| NBA 2022-03-06: TOR 96 at CLE 104 | Mar 06, 2022 | CLE | TOR | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-03-04: CLE 119 at PHI 125 | Mar 04, 2022 | PHI | CLE | Wells Fargo Center | Philadelphia | PA |
| NBA 2022-03-02: CHA 119 at CLE 98 | Mar 02, 2022 | CHA | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-02-28: MIN 127 at CLE 122 | Feb 28, 2022 | MIN | CLE | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-02-26: WAS 86 at CLE 92 | Feb 26, 2022 | CLE | WAS | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-02-24: CLE 103 at DET 106 | Feb 24, 2022 | DET | CLE | Little Caesars Arena | Detroit | MI |
| NBA 2022-02-15: CLE 116 at ATL 124 | Feb 15, 2022 | ATL | CLE | State Farm Arena | Atlanta | GA |
| NBA 2022-02-12: CLE 93 at PHI 103 | Feb 12, 2022 | PHI | CLE | Wells Fargo Center | Philadelphia | PA |
| NBA 2022-02-11: CLE 120 at IND 113 | Feb 11, 2022 | CLE | IND | Gainbridge Fieldhouse | Indianapolis | IN |
| NBA 2022-02-09: SAS 92 at CLE 105 | Feb 09, 2022 | CLE | SAS | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-02-06: IND 85 at CLE 98 | Feb 06, 2022 | CLE | IND | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-02-04: CLE 102 at CHA 101 | Feb 04, 2022 | CLE | CHA | Spectrum Center | Charlotte | NC |
| NBA 2022-02-02: CLE 104 at HOU 115 | Feb 02, 2022 | HOU | CLE | Toyota Center | Houston | TX |
| NBA 2022-01-31: NOP 90 at CLE 93 | Jan 31, 2022 | CLE | NOP | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-01-30: CLE 105 at DET 115 | Jan 30, 2022 | DET | CLE | Little Caesars Arena | Detroit | MI |
| NBA 2022-01-26: MIL 99 at CLE 115 | Jan 26, 2022 | CLE | MIL | Rocket Mortgage FieldHouse | Cleveland | OH |
| NBA 2022-01-24: NYK 93 at CLE 95 | Jan 24, 2022 | CLE | NYK | Rocket Mortgage FieldHouse | Cleveland | OH |